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Poison management facilities throughout the nation are fielding an increasing number of requires assist associated to unintentional overdoses of semaglutide, the lively ingredient in Wegovy and Ozempic, the brand new injected medication for weight reduction and diabetes.
There have been nearly 3,000 calls associated to semaglutide this yr, in accordance with knowledge tracked from January via November of 2023 by America’s Poison Facilities. That quantity is almost double the quantity reported in 2022. Altogether, calls associated to semaglutide have surged roughly 1,500 % since 2019.
“I consider calls are rising as a result of the general use of the remedy is rising,” says Julie Weber, a registered pharmacist and director of the Missouri Poison Middle and a board member of America’s Poison Facilities.
Semaglutide Overdose Can Trigger Critical Gastrointestinal Points
Most frequently overdoses associated to semaglutide trigger gastrointestinal points like nausea, vomiting, and stomach ache, Weber says. Some individuals additionally expertise complications, dizziness, or shaking.
However in rarer, extra severe instances, individuals can expertise extreme vomiting that results in excessive dehydration and electrolyte imbalances. “If left uncorrected, this might be life threatening,” Weber says.
Unintentional overdoses of semaglutide have surged lately as extra injected medication containing this ingredient have come available on the market to deal with diabetes and support weight reduction. Ozempic, the primary drug in a household of medicines often called GLP-1 agonists that include semaglutide, was authorised by the U.S. Meals and Drug Administration (FDA) in 2017 to deal with kind 2 diabetes. Two years later, the FDA cleared one other drug made with semaglutide, Wegovy, for weight reduction.
“Unintentional remedy errors account for many of the enhance in reported instances to poison facilities,” says Gary Smith, MD, DrPH, director of the Middle for Damage Analysis and Coverage at Nationwide Kids’s Hospital.
Ozempic and Wegovy Dosing Errors
Ozempic and Wegovy are bought as pens that may inject a preselected dose, which ought to restrict the potential for unintentional overdoses, says Joseph Lambson, PharmD, director of the New Mexico Poison and Drug Info Middle in Albuquerque.
“That being stated, overdose is feasible with pens that may present completely different doses if sufferers choose the inaccurate dose,” Dr. Lambson says.
Persistent brief provide and excessive demand for Ozempic and Wegovy may additionally be not directly contributing to some unintentional overdoses, Lambson says. That’s as a result of shortages are main extra individuals to hunt out compounded types of semaglutide, that are bought in vials and require individuals to make use of a needle and syringe to attract up the right dose to inject on their very own, Lambson.
“It’s extra widespread for sufferers to expertise dosing errors when drawing up their very own medicines in comparison with pre-filled pens or syringes,” Lambson says. “This, along with the recognition of the drug, is more than likely contributing to the elevated name quantity we’re experiencing.”
In New Mexico, poison facilities have fielded some calls from sufferers who unintentionally took a double dose of semaglutide, injected the medication too quickly after their earlier dose, or who misunderstood the dosing directions, Lambson says. Whereas nobody has died, 43 % of the individuals who referred to as about unintentional semaglutide overdoses did require fast medical consideration.
What to Do if You Assume You’ve Taken Too A lot Semaglutide
Signs of a semaglutide overdose like nausea, vomiting, or stomach ache could be regular unwanted effects of Ozempic and Wegovy that develop even when individuals take the drug as prescribed. Weber advises anybody who experiences these signs and isn’t positive what to do ought to contact their well being care supplier or name their native poison management heart at 800-222-1222.
“By contacting the poison heart, a medical knowledgeable instantly is accessible to assist consider whether or not medical care needs to be sought or present steering for dwelling remark,” Weber says.
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