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From Diabetes Every day
Ozempic is probably the most hyped diabetes drug ever. It looks as if the entire world is speaking in regards to the drug, which was authorized in 2017 however solely grew to become a social media weight reduction sensation in 2022.
One stunning results of Ozempic’s meteoric rise has been an unprecedented public concentrate on the drug’s unwanted side effects. With so many individuals sharing their experiences within the public sq., we’re studying about Ozempic’s peculiar results in a manner that even a section 3 trial may by no means reveal. Each few weeks, it appears, we hear that TikTok customers are shining a lightweight on one other new Ozempic aspect impact.
This text will element every thing we learn about Ozempic unwanted side effects — the nice, the unhealthy, the scientifically verified, and the anecdotal.
A short be aware: This text makes use of the model identify Ozempic to check with semaglutide, the drug’s energetic ingredient. Semaglutide can also be marketed below two different names, Wegovy (when it’s offered for weight reduction) and Rybelsus (when it’s within the type of a capsule slightly than an injection). Different associated medicine, similar to liraglutide (Victoza) and tirzepatide (Mounjaro), might or might not trigger a number of the similar unwanted side effects.
Gastrointestinal Facet Results: Nausea, Diarrhea, Vomiting, Stomach Ache, and Constipation
These uncomfortable tummy troubles make up Ozempic’s most typical and most mentioned unwanted side effects by far.
Whereas a majority of customers don’t understand these pains, a considerable minority do. And for some, the gastrointestinal misery is simply an excessive amount of to deal with, and they should cease taking Ozempic completely. As a blogger for New York journal’s “The Lower” put it, “You may undergo Hell on your post-Ozempic physique.” The creator spoke to a 42-year-old lady with diabetes who endured “fixed nausea” and “power-puking” for weeks, earlier than lastly weaning herself off the drug.
In accordance to the U.S. Meals and Drug Administration (PDF), placebo-controlled trials of Ozempic discovered the next charges of unwanted side effects from the 1 milligram (mg) dose:
Smaller numbers reported signs similar to acid reflux disorder and extreme belching or flatulence.
All instructed, 30.8 % of adults reported a gastrointestinal symptom. However that was solely the 1 mg dose, half of the utmost. The numbers have been a lot greater in a trial of semaglutide (Wegovy) at 2.4 mg in folks with out diabetes:
- Nausea: 44.2 %
- Vomiting: 24.8 %
- Diarrhea: 31.5 %
- Stomach ache: 10.0 %
- Constipation: 23.4 %
At this, the best dosage of semaglutide obtainable, an unbelievable 74 % of individuals skilled at the very least one gastrointestinal dysfunction, although it’s price noting that just about 50 % of those that took a placebo additionally had some tummy troubles. Solely 4.5 % of the semaglutide sufferers stopped taking the remedy as a direct results of gastrointestinal issues.
Studies from the Diabetes Every day discussion board recommend that these unlucky results are strongest within the days instantly after injecting the once-weekly remedy. Sufferers are additionally almost definitely to expertise issues after they begin on the drug or after they step as much as the next dosage; the unwanted side effects generally fade away because the physique will get used to the drugs.
What’s one of the simplest ways to cope with these nasty issues? We have now a complete article on the topic.
Ozempic Burps
A foul-smelling burp isn’t precisely probably the most debilitating of unwanted side effects, but it surely’s price understanding about. As reported in The Atlantic, and mentioned in lots of TikTok movies, some folks with Ozempic discover themselves emitting nasty sulfurous smells after they belch. There’s broad settlement that the burps scent like rotten eggs.
Solely a minority of individuals expertise sulfurous burps, doubtless fewer than 10 %. Anecdotal studies recommend that the burps, like different gastrointestinal points, are worst when sufferers start taking their medicine or step as much as greater dosages.
TikTok is filled with ideas, from amateurs and docs alike, on what meals set off eggy burps and the right way to do away with them.
Bloating and Farting
These uncomfortable unwanted side effects have been reported in medical trials as “belly distension” and “flatulence.” Bloating and farting complaints are much less widespread than the gastrointestinal results mentioned above, they usually have but to catch on as sizzling matters on social media, but it surely’s good to know that Ozempic and associated medicine might improve their probability.
Ozempic Face and Ozempic Butt
“Ozempic face” might have been the primary Ozempic aspect impact to go viral. In January 2023, everybody was speaking about this rumored aspect impact, which was lined lavishly within the mainstream media. In June 2023, the sample repeated itself when claims of “Ozempic butt” hit headlines. In every case, customers complained that the drug had given them a stunning and unlucky flabby look, within the face, within the derriere, or maybe in each.
There’s nothing to fret about. There isn’t any proof that Ozempic or another related drug straight acts in your look. Consultants agree that Ozempic face and Ozempic butt are purely brought on by weight reduction. The identical flabby consequence can happen once you drop some weight the old style manner.
If you lose lots of weight, you may also lose a number of the healthy-looking fats in your face. Speedy weight reduction can even result in flabby pores and skin: The pores and skin is an adaptable and elastic organ, but it surely can’t snap immediately again right into a taut form. Profitable dieters have struggled with these points since lengthy earlier than Ozempic got here on the scene.
Hair Loss
Ozempic can trigger hair loss. Whereas it isn’t listed as a aspect impact on Ozempic’s FDA label, hair loss is listed on the official label for Wegovy, basically the identical remedy. Three % of individuals within the drug’s pivotal trial reported hair loss (thrice as many as those that used a placebo).
Like Ozempic face and Ozempic butt, nonetheless, this isn’t a worrying chemical impact of the medicine however slightly an inevitable consequence of speedy weight reduction. Dramatic weight reduction, regardless of the way it’s triggered, typically causes hair loss. For instance, a 1974 examine of crash dieters discovered a number of instances of “profuse hair loss.” And greater than half of people that obtain bariatric surgical procedure expertise hair loss, too.
The excellent news: A 2017 examine discovered that “hair loss stopped and new hair progressively grew out in all sufferers.” Hopefully, the minority of Ozempic customers that lose some hair on the drug may have the identical good luck.
Fatigue
There are studies that Ozempic could cause fatigue — principally, tiredness or exhaustion that isn’t improved by sleep. The FDA label for semaglutide (Wegovy) studies that 11 % of trial individuals skilled fatigue, a bit bit greater than twice as typically as those that used a placebo.
It’s unclear why Ozempic would trigger fatigue, though one very believable clarification is the truth that it causes folks to eat a lot much less meals. Ozempic causes excessive weight reduction by encouraging customers to eat at an excessive calorie deficit. You’re placing much less gasoline into your physique. Is it any surprise {that a} crash weight loss program can sap your power?
Dizziness
Dizziness has additionally been reported in a slim minority of Ozempic customers. It’s doable that Ozempic dizziness stems from the glucose-lowering results of the drug — dizziness is a standard symptom of hypoglycemia. Even sufferers who aren’t liable to extreme hypoglycemia (usually these that don’t use insulin or sulfonylureas) might really feel dizzy whereas experiencing transient low blood sugar episodes.
Muscle Loss
It’s inevitable that weight reduction will contain some muscle loss. That is thought of wholesome and pure.
Some consultants, nonetheless, imagine that Ozempic and associated medicine are inflicting a stunning and worrying quantity of muscle loss, greater than we see with different weight reduction strategies.
We solely have a modicum of fine knowledge on this query. Physique composition analyses of volunteers in two trials discovered that semaglutide customers misplaced about 40 % lean mass and 60 % fats. A 2017 overview states that dieters utilizing different strategies to drop some weight are likely to lose solely 20 to 30 % lean mass.
The science right here stays unsettled; we don’t know if Ozempic causes additional muscle loss. Both manner, consultants agree that it could be smart for Ozempic customers to interact in strength-building workouts to assist protect muscle mass throughout weight reduction. Consuming sufficient protein may additionally assist.
This potential aspect impact may additionally be an excellent reminder that Ozempic is inappropriate for individuals who would not have an excellent medical cause to drop some weight.
Ozempic Desires
Behold, probably the most beguiling of all Ozempic unwanted side effects: the Ozempic dream. In April, The Wall Road Journal reported that many customers have been experiencing unusual vivid goals, typically involving celebrities.
It’s inconceivable to know if this can be a actual aspect impact or only a social media confabulation, although some consultants have speculated on ways in which the drug — or the load loss it creates — may improve vivid dreaming.
Addictive and Compulsive Conduct Reduction
Many Ozempic customers are amazed to seek out that they’re participating in much less addictive and compulsive habits. One way or the other the drug seems to scale back our damaging tendency to overindulge in actions like ingesting, buying, playing, or to compulsively choose at our pores and skin or chunk our nails. The Atlantic not too long ago puzzled, “Did scientists by chance invent an anti-addiction drug?”
The science right here continues to be in its infancy, however it seems that one of many causes Ozempic is ready to stem starvation cues is by performing straight within the mind. We all know that Ozempic doesn’t simply provide help to really feel full quicker, it really lowers your longing for meals. And it appears as if it reduces your longing for different issues, too.
Consultants have recognized for years that GLP-1 receptor agonists may need these behavioral results. In a 2022 examine of exenatide (Byetta), mind scans confirmed that the drug lowered exercise in “essential mind areas for drug reward and habit.” It additionally calmed down the mind’s dopamine circuitry.
We’re years away from the day that Ozempic or any associated drug will likely be prescribed as a remedy for addictive or compulsive habits. However within the meantime, it may assist customers with extra than simply compulsive consuming.
Coronary heart Price Will increase
There’s been surprisingly little on-line chatter about this aspect impact, which is famous on Ozempic’s FDA label. In medical trials, decrease doses of Ozempic “resulted in a imply improve in coronary heart fee of two to three beats per minute.” Some sufferers, like a girl profiled by The Lower, discovered the expertise extraordinarily uncomfortable.
The FDA advises sufferers to “inform their healthcare suppliers of palpitations or emotions of a racing heartbeat whereas at relaxation.” Sufferers that skilled “sustained” will increase in resting coronary heart fee ought to discontinue the remedy.
Worsening Eyesight
Individuals with diabetes ought to know that there’s some proof that semaglutide (Ozempic) might improve the incidence of diabetic retinopathy. One in all a number of pivotal research of semaglutide discovered an elevated threat of DR, and the FDA has reported {that a} considerably greater share of Ozempic customers have DR as compared with customers of comparable medicine like dulaglutide (Trulicity) and liraglutide (Victoza). The connection is disputed, nonetheless, as one other massive examine of semaglutide discovered no such threat.
If the connection is actual, it appears doable that Ozempic’s unbelievable effectiveness explains its detrimental impact on the eyes. Opposite to all expectations, speedy enchancment in glucose management can really worsen diabetic retinopathy. That is known as “early worsening,” as a result of the eyes will worsen earlier than the key long-term advantages of higher blood sugar management develop into evident.
A current dialogue of the problem by consultants from the American Academy of Ophthalmology advised that “early worsening” from Ozempic is each “momentary and manageable,” though it does name for elevated scrutiny from eye docs.
Hypoglycemia
Whereas Ozempic in all probability doesn’t itself trigger hypoglycemia, its glucose-lowering impact can sharply improve the chances that insulin or sulfonylureas trigger hypoglycemia.
You probably have diabetes and also you’re beginning a brand new GLP-1 receptor agonist, it’s doable that you simply’ll want to alter the dosages of the opposite diabetes medicine that you simply use. Your physician may additionally ask you to be additional vigilant about checking your blood sugar. In the event you’re not comfy altering your insulin-dosing practices by your self, you need to be able to contact your physician between visits to get clearance for making changes.
Uncommon, Severe Facet Results
Semaglutide additionally results in a small variety of uncommon however doubtlessly severe unwanted side effects:
- Pancreatitis, through which the digestive enzymes assault the pancreas, might really feel like intense abdomen ache that radiates to your again.
- Kidney failure. There have been some instances of semaglutide contributing to kidney illness. Dehydrating unwanted side effects, significantly diarrhea and vomiting, might improve this threat.
- Gallbladder illness might current with extreme abdomen ache, yellowing of the eyes or pores and skin, fever, and “clay-colored stools.”
- Thyroid C-cell tumors. It’s unknown if semaglutide really causes these doubtlessly cancerous tumors in people, but it surely has been noticed in research of rodents.
There have additionally been some studies of allergic reactions to GLP-1 receptor agonists.
Ozempic is highly effective stuff: In the event you’re experiencing a response which you can’t clarify, please attain out to your healthcare supplier.
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